The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and somewhat soluble in alcohol. The molecular pounds is 406.37. Its molecular method is C18H21NO3•H3PO4 • ½ H2O, and it has the next chemical composition.
Excessively massive dosages of antihistamines, including promethazine hydrochloride, in pediatric patients might lead to sudden Demise (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric sufferers. In pediatric patients who're acutely unwell related to dehydration, There may be an increased susceptibility to dystonias with using promethazine HCl.
are pregnant or approach to become Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Remedy can hurt your unborn child. See “What exactly is the most important facts I should learn about Promethazine Hydrochloride and Codeine Phosphate Oral Option?” are breastfeeding or plan to breastfeed. Codeine passes into your breast milk and could cause really serious Negative effects as part of your baby such as improved sleepiness, respiration complications (respiratory despair), and Dying. It isn't acknowledged if promethazine can move into your breast milk.
Antiemetics will not be suggested for treatment of uncomplicated vomiting in pediatric sufferers, and their use must be restricted to prolonged vomiting of identified etiology. The extrapyramidal signs or symptoms which could take place secondary to Promethazine HCl Oral Solution administration may very well be puzzled Using the CNS indications of undiagnosed Principal illness, e.g., encephalopathy or Reye's syndrome. The usage of Promethazine HCl Oral Answer need to be avoided in pediatric sufferers whose indicators and indications may possibly suggest Reye's syndrome or other hepatic conditions.
Promethazine and codeine may well cause marked drowsiness or may well impair the psychological and/or Actual physical skills essential with the general performance of probably harmful jobs, like driving a auto or operating machinery.
Narcotic analgesics cross the placental barrier. The nearer to shipping and delivery as well as the much larger the dose utilized, the increased the possibility of respiratory depression from the new child. Narcotic analgesics should be prevented all through labor if shipping of the premature toddler is predicted.
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Very low blood pressure. A unexpected more info drop in blood pressure level can occur in some people for the duration of cure with Promethazine Hydrochloride and Codeine Phosphate Oral Solution which may trigger you to sense dizzy, faint, lightheaded, or weak, especially when you rise up (orthostatic hypotension). Your threat of getting this issue can be increased if you take Promethazine Hydrochloride and Codeine Phosphate Oral Resolution with sure other medicines that reduced blood pressure level.
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It is far from regarded regardless of whether Promethazine HCl is excreted in human milk. Due to the fact several medications are excreted in human milk and due to the likely for critical adverse reactions in nursing infants from Promethazine HCl Oral Option, a choice must be produced no matter whether to discontinue nursing or to discontinue the drug, making an allowance for the necessity of the drug for the mother.
Make sure sufferers have an oral dosing dispenser that measures the right volume in milliliters. Counsel patients regarding how to use an oral dosing dispenser and properly measure the oral suspension as prescribed.
The opioid antagonists, naloxone and nalmefene, are distinct antidotes for respiratory melancholy resulting from opioid overdose. For clinically sizeable respiratory or circulatory despair secondary to codeine overdose, administer an opioid antagonist. An antagonist shouldn't be administered inside the absence of clinically considerable respiratory depression. As the length of opioid reversal is expected to generally be less than the period of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Remedy, cautiously observe the client until finally spontaneous respiration is reliably reestablished.
Clearance could possibly be lessened as well as metabolites may well accumulate to Substantially increased plasma amounts in individuals with renal failure as compared with individuals with ordinary renal purpose.
Promethazine Signals and signs or symptoms of overdosage with promethazine vary from moderate depression of your central nervous technique and cardiovascular process to profound hypotension, respiratory depression, unconsciousness and sudden Demise.